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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK12 All Species: 30.3
Human Site: S180 Identified Species: 55.56
UniProt: P53778 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53778 NP_002960.2 367 41940 S180 G L A R Q A D S E M T G Y V V
Chimpanzee Pan troglodytes Q95NE7 360 41475 D177 G L A R H T D D E M T G Y V A
Rhesus Macaque Macaca mulatta XP_001112462 367 41940 S180 G L A R Q A D S E M T G Y V V
Dog Lupus familis XP_848658 287 32890 V106 D S E M T G Y V V T R W Y R A
Cat Felis silvestris
Mouse Mus musculus O08911 367 42025 S180 G L A R Q A D S E M T G Y V V
Rat Rattus norvegicus Q63538 367 41967 S180 G L A R Q A D S E M T G Y V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509537 374 42522 S177 G L A R H A D S E M T G Y V V
Chicken Gallus gallus XP_001233062 310 36087 T129 R H T D S E M T G Y V V T R W
Frog Xenopus laevis P47812 361 41700 E178 G L A R H T D E E M T G Y V A
Zebra Danio Brachydanio rerio O42376 363 41952 S178 G L A R Q T D S E M T G Y V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61443 365 42080 S180 G L A R P A E S E M T G Y V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17446 377 43900 S188 G L A R Q T D S E M T G Y V A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q96TL5 358 41225 P168 G L A R I Q D P Q M T G Y V S
Conservation
Percent
Protein Identity: 100 61.8 99.1 74.1 N.A. 92.6 93.7 N.A. 66.5 65.4 60.2 67.8 N.A. 56.9 N.A. 54.6 N.A.
Protein Similarity: 100 77.6 99.1 75.7 N.A. 95.9 96.1 N.A. 77.5 76.5 76.5 81.7 N.A. 73.8 N.A. 72.1 N.A.
P-Site Identity: 100 73.3 100 6.6 N.A. 100 100 N.A. 93.3 0 73.3 93.3 N.A. 80 N.A. 86.6 N.A.
P-Site Similarity: 100 73.3 100 6.6 N.A. 100 100 N.A. 93.3 6.6 73.3 93.3 N.A. 86.6 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 46.5
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 65.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 66.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 85 0 0 47 0 0 0 0 0 0 0 0 39 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 8 0 0 77 8 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 8 8 8 77 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 85 0 0 0 0 8 0 0 8 0 0 85 0 0 0 % G
% His: 0 8 0 0 24 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 85 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 8 0 0 8 0 0 85 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 47 8 0 0 8 0 0 0 0 0 0 % Q
% Arg: 8 0 0 85 0 0 0 0 0 0 8 0 0 16 0 % R
% Ser: 0 8 0 0 8 0 0 62 0 0 0 0 0 0 8 % S
% Thr: 0 0 8 0 8 31 0 8 0 8 85 0 8 0 0 % T
% Val: 0 0 0 0 0 0 0 8 8 0 8 8 0 85 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % W
% Tyr: 0 0 0 0 0 0 8 0 0 8 0 0 93 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _